0
Categories
How To Order | Shipping Policy | FAQ | Contact Us

Customer Support: +18102015692
Refer Friend

Avanafil
Avana

  • Stendra
  • ED000
  • In Stock

Premium High Quality Product & Original Active Substance!

Select Doses:

   Manufacturer's Suggested Retail Price (MSRP) per pill is $9.26 ! Buying from us will save you at least 43.84%

Package per pill Price SAVINGS BONUS Order
50mg * 8 pills
$5.20 $41.60 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
50mg * 16 pills
$4.11 $65.76 $17.44
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
50mg * 24 pills
$3.81 $91.44 $33.36
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
50mg * 32 pills
$3.65 $116.80 $49.60
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

   Manufacturer's Suggested Retail Price (MSRP) per pill is $13.14 ! Buying from us will save you at least 45.36%

Package per pill Price SAVINGS BONUS Order
100mg * 8 pills
$7.18 $57.44 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 16 pills
$5.81 $92.96 $21.92
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 24 pills
$4.75 $114.00 $58.32
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg * 32 pills
$4.36 $139.52 $90.24
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

   Manufacturer's Suggested Retail Price (MSRP) per pill is $21.83 ! Buying from us will save you at least 45.95%

Package per pill Price SAVINGS BONUS Order
200mg * 4 pills
$11.80 $47.20 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
200mg * 8 pills
$11.71 $93.68 $0.72
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
200mg * 12 pills
$10.88 $130.56 $11.04
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
200mg * 16 pills
$9.95 $159.20 $29.60
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer. FDA approved on April 27, 2012.

Avanafil is used to treat erectile dysfunction (impotence). Avanafil should not be taken by a woman or a child.

Does not directly cause penile erections, but affects the response to sexual stimulation. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Avanafil may also be used for purposes not listed in this medication guide.

Avanafil is a strong, competitive inhibitor of PDE5. It is also 100-times more potent for PDE5 than PDE6. The IC50 of avanafil is 5.2 nM. Compared to other PDE5 inhibitor like sildenafil and vardenafil, it is 16- and 21-fold more selective for PDE5 respectively. Avanafil does not bind to PDE6 and PDE11 to a considerable degree.

The impact of this finding is that avanafil is less likely to cause side effects such as visual disturbances and myalgia. These are side effects that patients on sildenafil or tadalafil are more likely to experience. Furthermore, single oral doses of avanafil (200 mg) administered to healthy male volunteers resulted in mean changes from baseline in systolic/diastolic blood pressure of -5.3/-3.7 mmHg at 1 hour after dosing.

Avanafil does not causes changes in QTc interval or ventricular repolarization.

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum.

The inhibition of phosphodiesterase type 5 (PDE5) by avanafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Avanafil is hepatically metabolized primarily by the enzyme, CYP3A4. Two major metabolites are formed, M4 and M16. M4 has 4% of the pharmacologic activity of avanafil. M16 is an inactive metabolite.

Absorption: Avanafil is rapidly absorbed and does not accumulate following multiple doses. Tmax = 30 - 45 minutes; Time to peak response = 10 minutes (20 minutes shorter than sildenafil)

Route of elimination: After oral administration, avanafil is excreted as metabolites predominantly in the feces (approximately 62% of administered oral dose) and to a lesser extent in the urine (approximately 21% of the administered oral dose).

Half life: Mean elimination half-life = 5.36 - 10.66 hour

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Avanafil.

Tell your doctor or pharmacist if you have any medical conditions.

Avanafil is generally well tolerated. The most commonly reported adverse event are headache and facial flushing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Jud
12/Jan/2024

Excellent Med this Avana pill. A tip for all you guys suffering hip and back pain after use of some ED meds, cause is likely not the meds. Now in my 60's, while in my 20's I could stay on the ride for hours until I decided when it would end. After some back and cervical injuries slowed me down the staying on the ride power with remains as long as I take the right ED med. As we get older though so do our bones, muscle and everything else. Now days, we pop a med, pop an erection and suddenly when in the saddle giving it all we have as if we were still 20 something. Damn right your backs and hips are going to ache :) Not the meds ;)

Manny
01/Jan/2024

I have tried Viagra and Levitra. No luck. Avana 200mg with and without food, with foreplay I get a very good hard erection in about 30 min. Wife and I can go for ages, take a break and go again. It seems like the next morning I am able to get that great erection again. We love it, and I have had no side effects.

Shaun
31/Dec/2023

Very prompt delivery! It was worth spending a few extra dollars just for getting the drugs I need on time. I can't wait for my next order to arrive.

Graham
25/Dec/2023

Love this new super-pill! Fewer side effects than Viagra or Cialis last twice as long as Viagra and start in as little as 15 minutes. I've used Viagra as well as Cialis and Avana is better in all aspects and ways hands down!

Sahab
21/Oct/2023

This medication is just amazing!!! Worked in 15 minutes and my wife thought I was an amazing! We went at it for 70 minutes! I kid you not! Never had any issues with Avana in the past 10 months. Viagra and Cialis just don't work as good as this one. At least for me that's the case!

Write a review

Note: HTML is not translated!
    Bad 
 
 
 
 
 Good
TOP